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KMID : 0604020110260030134
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Korean Journal of Critical Care Medicine
2011 Volume.26 No. 3 p.134 ~ p.138
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Effect of Caffeic Acid Phenethyl Ester on Lipopolysaccharide-induced Murine Macrophage Activation
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Lee Seong-Heon
Li Mei
Lee Dae-Wook
Lim Dong-Yun
Jeong Cheol-Won
Kwak Sang-Hyun
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Abstract
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Background: Caffeic acid phenethyl ester (CAPE) is an active component of propolis and is known to have anti-inflammatory properties. This study was performed to evaluate the effects of CAPE on lipopolysaccharide (LPS)-induced murine macrophage activation.
Methods: Raw 264.7 cells were incubated with varying concentrations of CAPE with or without LPS. The production of tumor necrosis factor-alpha (TNF-?), interleukin (IL)-1? and macrophage inflammatory protein-2 (MIP-2) and activation of extracellular signal-regulated kinases 1/2 (ERK1/2), c-Jun amino terminal kinases (JNK) and p38 were measured.
Results: CAPE inhibited the production of TNF-?, IL-1? and MIP-2 and attenuated phosphorylation levels of ERK1/2 and p38, but not JNK in RAW264.7 cells stimulated with LPS.
Conclusions: CAPE can attenuate LPS-induced macrophage responses and we suggest that these effects may play an important role in modulating macrophage-mediated inflammatory responses in vivo.
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KEYWORD
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caffeic acid phenethyl ester, cytokines, mitogen-activated protein kinases
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